I have the wonderful honor of experiencing a number of painful partial depressurization events at FL450 (45,000 feet). Our company had a Gulfstream GIII that, due to a bad "outflow valve", would suddenly "fry" a TO-3 controller drive transistor (it ran AC motor on the outflow valve). The maintenance staff would get warranty replacement for the failed controller, which would hold up for a few more flights, and then fail in the same way. The fix was very expensive and they knew what was needed, a new outflow valve. We operated that way for about a year until the boss experienced the event, and then the maintenance staff had no choice but to spend the money. To this day, I remain annoyed at the person who managed the plane this way.
The plane would depressurize at a modest rate (not explosive) and fog up. What was interesting is that the aural (audio) warning and visual red warnings were both completely impossible to hear and see. I learned to quickly Don the O2 mask and select 100% O2 and first exhale before inhaling deeply. I'd then select manual control on the outflow valve and drive it closed, FAST. I could do this in 4 or 5 seconds due to practice.
Once we did have an older pilot pass out, as he did not get his mask on fast enough. He was still unwell hours later and tried to land on the wrong runway.
In any case, we'd manage the plane by manually controlling the outflow valve. Using bleed air from only one engine, and making power changes with the other engine. That way, our ears were not going crazy with each power change.
By the way, it is a miserable and painful experience to suddenly lose pressurization like that.
Note: the manual cabin pressure control knob is on the overhead panel, to the right.
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