If this pistol is your defense gun, IMNSHO (In My Not So Humble Opinion), clean it thoroughly after each use. the .22 rimfire is far more likely to have mechanical problems if there is much firing residue (dirt), than a more powerful cartridge. If it's a fun gun, I'd do as Bill says. I clean mine because I first learned how to shoot in the Army, and we kept everything clean and ready. Of course, we knew that the Group of Soviet Forces Europe was only 2km. away. One would expect to give the "warmest" possible welcome to visitors, wouldn't one?