Until I got the Highlander, the only driving aids I was accustomed to is auto on headlights and the tilting RH rear view mirror (I keep it off) on the LS400.
I turned the lane tracking assistance off in the Highlander. The tilting rear view mirrors are also turned off. Found out if you don't go through a setup routine, the rear view mirrors will actually tilt up when in reverse.
I don't know about other makes but it would be nice if the rear view camera had better resolution. I guess as long as you can make out moving objects it's good enough. I still look over my shoulders when backing.
I use the ACC, set to 75mph and adjust the following distance according to traffic conditions; more distance when traffic slows, less when traffic is moving at a good clip. I've had the ACC brake hard enough to trigger the ABS. I still cover the brake, it's a trust issue.
I used to think most of these aids were bothersome. But I'm getting used to them being there. I just don't want to get into the habit of totally relying on them. Nothing is fool-proof (I'm a fool...ask anyone who knows me).
You probably know this, but I recently discovered you can temporarily silence the warning buzzer/chimes by pressing the "OK" button on the steering wheel controls.