Cameras are game changers, especially backing up.
Mirrors are another reason I prefer trucks. On the Super Duty trucks, I keep the lower convex mirror showing the ground, rear tires, and a good chunk of the pickup box. Ideal for towing trailers and maneuvering in tight spots. Also good for keeping an eye on the trailer and it's tires. I keep the main mirrors adjusted as suggested; way out so I see the lanes next to me. I also keep my seat up as high as it will go. I like a commanding view and I want to see up and over the hood because I often have to park up close to other vehicles or equipment.
Set up like this in such a large truck, I see everything as I go down the road.
Again, there is a learning curve adjusting the mirrors as suggested. I used to keep my mirrors adjusted to just see the side of the vehicle, but if you're honest with yourself on what the mirrors are for and are willing to go through the re-adjustment/learning curve, it is a safe way to keep them adjusted.