depends on where you are going.
When we needed lodging for 10 guys in florida, we found it worthwhile.
For just myself and my wife on a weekend trip, it is more cost effective to get a hotel.
Many of them charge huge cleaning fees, and big deposits.
As you know, being in orlando, many of the large chains own family style rooms which is as large as a home, and you can pay hotel type prices for it.
We rented a 3 bedroom apartment from Holiday Inn vacations in orlando for like $179 per night. Did the same thing in galveston last month.
VRBO would have charged you that same fee, plus a 75 dollar cleaning fee, and a hefty deposit.