It’s interesting. I think many people would prefer to use one hand or the other for manipulating control equipment. Anyone training to fly these planes would be using their right hand until they were training to be captain, but now they would be using their left hand. Also, left brained people ( who tend to be right handed, would be using their left hand to operate the joy stick.) Then there are right brained people who tend to be left handed and are known to be talented arty people, who shouldn’t be flying airplanes. Flame suit on.
Even most center sticks are obviously designed around right handed thumb control.
I personally would freak out if I had to drive a right-hand drive manual transmission. There's just too much muscle memory. However, I'm sure that pilots get plenty of simulator time before trying out the real thing. I mean - lefties learn how to drive when everything in a car is based on primarily using the right foot. I've learned how to use my left foot to engage a clutch pedal. These are things that seem like they're fixed, but they're still learned.