I've never attacked this problem with any specific plan, which means I've tried different things. Rarely used equipment like snow blowers tend to get run dry at the end of the season. Mowers sit out the winter with gas in them, but that gas is treated with Sta-Bil. My oldest piece of OPE, a Troy-Bilt Pony rototiller dating back to 1985, needed a new carb last spring. Presently I purchase Ethanol-free fuel and also treat it with Sta-Bil when it is going to sit for a while.
On the 2-cycle front, everything I owned failed about five years ago and was more economical to replace. Now I run the pre-mixed Ethanol free Tru-Fuel in all of the 2-cycle machines.