I use to work in a lab where we handled nasty stuff from time to time, and we figured out that that you don't want to use a solvent on something that will enhance absorbtion into the skin. In general that means lots of soap and water, and to try avoid things like alcohol, acetone, thinner, etc. But, paint is paint and you need to use a solvent. Before working on the vehicles I'll trim my nails nice and short, and if I remember to do so I'll put some hand cream on as it works as kind of a light shield for dirt. I use a good detergent, although not the best we use Palmolive with the anti-bacterial stuff for dish and hand soap, and a good brush. Even if you use some type of dedicated hand cleaner a brush still works well.