Between myself and family with vehicles I drove maintained and stared helping dad in mid 70's. License since '85.
'83 Malibu Wagon needed tranny rebuilt, due to slipping at about 130k. Had regular changes prior but towed also. Intake gasket needed replacement around 200k. Sold it with about 300k.
'94 Ford Explorer at like 100k iirc - Tranny started leaking oil like crazy, broke down in front of AAMCO and needed rebuild. Had to go back 2x for Torque Converter and issues. Factory rebuilt would have been cheaper, faster, better warranty. Started having a lot more other maintenance needs that shouldn't have been. Lost confidence in it for DD for wife/kids.
'07 Sonata at 220k motor started vibrating a lot, I think balance shaft module chain slipped. Shop checked and said internal issue that would need a lot more digging to determine. Motor started spraying from somewhere timing chain area like next day, basically on way home from shop. Potential investment to repair far outweighed book value of car that was starting to rust underneath.
'04 CRV (father-in-laws) neglected trans fluid for way to long. Started having many shifting issues around 220k. Replaced fluid a couple times with factory and got much better. Also replaced Main crankshaft seal. At about 260k, 2nd gear didn't work anymore. Tried replacing all the solenoids, fluid a couple more times, external filter etc. It lived a hard life for many years. I nursed it for a good bit since he gave it to my kids but sometimes old/tired just happens.
'85 Chevy Astro - rear differential needed replacing under warranty.
Many other "maintenance/repair/replace" between all vehicles but not what I would consider major engine/tranny besides above. Inexpensive fixes not always but when you regularly take vehicles past 200k, that is what it is.