AFAIK, E85 doesn't have as many BTU's as petroleum does, uses a different additive system, and also doesn't give as much MPG as petroleum. Chevy seems to have the biggest selection of flex fuel vehicles, but I'm not sure which models (I'm going by the number of those little badges I see driving 'round town).
I did ask about Honda engines/vehicles being able to use it, as I drove by a station that offered it, and of course, the 50+ cent per gallon difference peaked my interest, so I called a reputable tech that I know. He said that if I want to destroy my fuel system, then go ahead, then told me that as of now, no Honda models are set up to burn this fuel.
Hopefully someone else will chime in here with some more specifics than what I offered. I also wish that (and not to be political about it) that we would weigh whether or not this is a viable, sustainable fuel without depleting the food supply, as I have heard that by making a serious go of this fuel nation wide, that would be a result.