I took my old 94 Geo Prizm all over in the 7 years I had it from 106K to 256K miles. Trips from STL to DEN were the longest.
Made a fair bit of coin in mileage reimbursement from my employer as it was about $0.10-0.11/mile to drive when all costs were considered. My reimbursement has been over $0.50/mile since I can recall. So getting paid 4x what it costs me to drive it makes sense.
Everything in our household save the 99 Grand Marquis I just acquired from my grandmother has over 130K on the clock.
We have a 2002 Camry with just under 260K miles. oilBabe's oldest son will be driving it back and forth to a local college starting next month. In her ownership since new, the only repairs have been a axle, a starter and last winter one of the coils went out. The only other work has been wear items brakes, tires, batteries, belts, struts and fluid changes.
It looks rough but is perfect for a 22 year old to knock around in.
My 03 Protege5 has 182K on the ticker and I'm headed out to Omaha, NE from the STL area tomorrow. I'll be banking probably 1000 miles reimbursement by the time the trip is done. Since it's a Japanese built Mazda, rust will get it before anything else. It's starting to appear in the hatchback and a few other spots. I drive it 20-25K/year, so I hope to get two more winters out of it before I move it on.
As long as you take care of a car, high miles is simply a number.
Sure, things can break. But they can also break on a brand new car. Infant mortality and all that sort of thing.