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After you add first bottle of Auto-Rx to your existing oil, (should be dino oil to work on rear main seal leak and if not "Dino" oil, you will have to change out synthetic to "Dino") for the sake of clarity we will say your running dino, drive 750 miles and change oil and filter. Now drive 1500 miles with just new oil and filter (no Auto-Rx). At 1500 mile mark add second bottle of Auto-Rx and drive 750 miles. Change oil and filter - Auto-Rx application is done. Your engine and seals have been cleaned. Auto-Rx does not swell seals we restore seal integrity by using petrol chemistry of "Dino" oil. It will make seal mate with firmness against metal. It can take, at this point, up to 3000 miles of driving to stop leak completely (nothing but "Dino" oil during this time). When leak stops use whatever oil you wish. Why won't it work with "Synthetic" oil? Because complex additive package does not work well with restoring seal pliabilty. The simple additive package found in "Dino" oil is fine and helps seals to adhere firmly to metal.