I have been using the Lubegard Red in our 2002 ES300 and it is a great product. I have relatively fresh fluid (drain/fill every ~25k miles) with a TIV compatible fluid. These act evenly lazier with WS or maxLife; not recommended. The Lubegard has resolved a very slight vibration at idle that I could not track down or remedy any other way. The car has 285k and honestly feels about like new. Currently I am drain/filing with Castrol Transmax High Mileage and it has really improved the (even when new) low-sped clunk and shifting oddities of this transmission. Castrol recommends it as a TIV substitute, and it is slightly thicker than TIV and with HM additives.
The base oil of the Lubegard product is unique and the main reason I use it - for cleaning, seal conditioning, etc. If you are able to get a synthetic with a decent ester oil component, like perhaps Redline or find out what % is in Mobil 1, you might not benefit from adding the Lubegard. But if you add it, drop an ounce of it in your PS system, too. Changing the PS pump and rear hoses (some prone to leaking) on this engine are awkward jobs.
So maintain the system by draining the reservoir and refreshing at each AT service, and drop an ounce of the Lubegard Red in it, too.
My understanding was that with Honda fluids, the compatible transmission additive was the "Platinum" as the additive chemistry was different. Definitely check the lubegard website before choosing one for a Honda transmission.
And as you pointed out in your last post, I'm also adding it to my GM transmission at the next service.
IMO, doing a cooler line flush would be far more efficient and there is just no reason not to do it vs. multiple more inefficient drain/fills. Do it once that way to set a baseline of clean fresh fluid, then drain/fill every 25k or so going forward. The filters on these are wire mesh - do not replace them with paper filters or you risk pump starvation (it has been reported at TN in the past). With only 108k on this transmission, I do not see strong need to drop the pan for this reason. swap 10/11 qts via the cooler lines in one go, add the lubegard and then don't worry for 25k.
Another note on these transmissions - they will give very different fill levels on the dipstick when measured hot vs. cold. I trust only the cold level - check it in on a cold car, running, after shifting through gears.