IS250: intake carbon deposit, and the concern of transmission problem down the road (expensive, low inventory in junkyard)
Integra: engine cooling system, rebuild may not last long
Corolla: only 3 speed auto, high rpm and loud on highway speed
Camry: V6 fuel economy is low
Prius V: potential HG issue, I know the hybrid battery life expectancy so it is ok.
Mazda5: rear strut life expectancy
Former, Escort: broken AC, broken struts, potential valve seat drop, it is quite fun otherwise.
Regal: the style is old and boring, the intake manifold gasket
Former, Taurus: transmission shift funny, brake rotors warp, low quality interior
I'm pretty forgiving on cars, other than reliability issues