I certainly would not worry about running some premix in a modern car or truck.
I have been running it in my 2017 Toyota Sienna for about 50K miles at roughly a 200-1 ratio of oil to mid grade gas.
why? it's direct injected, and I want a little lube for the high pressure fuel pump. If I'm on the road and have no oil, then I don't worry about it.
The octane of the 2 stroke oil could be as low as 50-60 octane from what I have been able to find out and I'm not certain of even that number.* At a 200-1 ratio, this will lower the octane of the fuel about .2 of a point. So my midgrade becomes 88.8 instead of 89
That is the only possible down side to using it that I can see.
You will NOT have carbon build up, smoke from the tail pipe or fouled plugs. That is thrown out in every thread, but no evidence to back it up.
*I got the 50-60 octane number from an article that said a 50-1 ratio would drop the octane about 1 point. I know regular motor oil can be as low as 20-30 octane, but they are not designed to burn as fuel.