I'm not sure about the amounts of the draw, but the AC in the Toyota/Lex hybrids is interesting. It's a purely electrically driven system and has no direct connection to the gas engine at all. It sucks juice from the traction battery, which powers a variable speed compressor which runs only when needed (of course) and when on, runs only as fast as necessary to provide the desired cooling. Of course, there's no free lunch. When the AC is really working, the battery clearly drains faster, and mileage will drop some (how much depends but it doesn't seem to change by more than about one mpg).
From an operational (driver's) perspective, what's really nice is how you simply never, ever feel any of the grab-and-fade, even in the Prius with its small I-4. And it always provides max cold air on demand, even if you're sitting in traffic just idling.
Drawbacks? The systems are all automatic only, with no manual option for those who'd prefer it.