I'm running it in two vehicles currently.
1) A 2006 Toyota Tundra V8 4wd. ATL was installed when I changed the ATF for the first time, at about 58,000 miles. This vehicle now has 136,000 miles on it.
2) A 2010 Toyota Camry 4 cylinder automatic. ATL was installed about 5,000 miles ago (Earlier this year)
Judging from seat of the pants, both cars shift very smoothly and reliably on ATL. They did before, as well - I cannot tell any difference, operationally, between the OEM fluid (Toyota WS) and Amsoil ATL.
At about 100K miles, I removed the transmission pan, for the first time, from the Tundra. It had run half its life on factory fill ATF, and the other half on ATL. I was astonished how clean it was inside, with only a trace of metalic sediment (presumably from clutches) around the magnets in the pan. I was very impressed.
I've never run it in a Honda. However, I did have a 2002 Odyssey years ago, and can sympathize with the worry on transmission failure. I had my used ATF analysed a couple of times, and I remember it had high aluminum readings. I was nervous about switching fluids on a potentially problematic transmission, given it was under extended warranty, so I just used OEM Honda fluid and changed it frequently. If I had to do it over again, I wouldn't hesitate to use ATL in that automobile.