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There were some initial problems with bolt-on counterweights, which resulted (as one Formula One designer told me) in "several deep holes being dug in the surface of a few racetracks". There are tensile and fatigue stress issues, as well as the inevitable fretting between contact surfaces and the requirement for highly developed fastener technology.
Having observed more than a couple of high cycle fatigue failures of turbine blades, with horizontal shaft rotating equipment, there is obviously a 2g difference in the centripetal acceleration at 12:00 versus 6:00.
Most of the genuine high cycle fatigue (calc'd at 170x10^6 cycles from crack to failure in most) ones that I've seen have ultimately failed at around 6:00, as evidenced by trajectories and consequential damage.