- Joined
- Dec 28, 2011
- Messages
- 5,061
Autophagy occurs once the metabolism has been in a catabolic state for a considerable time. When we eat we activate mTor, an anabolic process which allows us to easily put on weight because excess calories are deposited as body fat. It also allows us to gain muscle mass with exercise because in the anabolic state cell growth is accelerated. A few hours after eating AMPK is activated which is a catabolic process that is in full swing after 16 hours or more of fasting. While in a catabolic state the body derives most if it's required energy from burning body fat. After one to three days of being in a catabolic state autophagy peaks. An occasional two or three-day fast has been proven to be beneficial. Anabolic and catabolic states must be balanced for optimal metabolism. By otipmal I mean in terms of health. There are obviously goals other than optimal health.
You can tell by looking at a person if they spend more time in a catabolic or anabolic state. For example, compare a marathon runner to a powerlifter.
Thanks for the reply. Good info. I'm a little late to get back on this. I'm well versed in it. I spent a lot of time with a good friend who is our police surgeon on this. He has a cosmetic and wellness side hustle and he has access to studies most do not. I have no issue spewing my thoughts but medical advice I didn't want to get into the weeds as some people could have conditions, known or unknown, that could cause them harm.
It's been great for me. I experience bone on bone in my left knee posterior and knee cap area; I have needed a knee replacement for a few years. Low carb, gym, intermittent fasting, heck of a lot less IPA's, and my constant knee pain is rather diminished. I hiked my first 4k mountain in VT last year with excellent results. I hadn't been able to do that the last few years. The real test is coming this spring/summer/fall as I try my last 3 hikes needed to complete the 4k's in NH. I have the longer ones left to do.
Hope it helps others.