I respect Trav's opinion, but I don't even think I'd touch the head bolts myself. If they're loose, you'll know it with the coolant (either losing it or with a combusion gas check). And if you do find any that are loose, I'm not sure what you could do about it anyway; the threads would likely be ruined already, or would get ruined if you tightened them. Hand-tight wouldn't fix a leak either. If they're loose, a Time-sert repair is the only real fix anyway, so I guess I'd wait until I got some symptoms personally.
Coolant maintenance is as important on this car as any other. Aluminum engines don't produce flakes of rust in the coolant that many are accustomed to looking for, so coolant changes were often not done on time. DexCool is a 5 year/150,000 mile coolant, so the coolant should have been changed at least three times already (2001, 2006, 2011); I'll bet it hasn't been changed once.
These engines are very durable overall. Water pumps and starters are very easy to change, despite their locations. The engines generally get poor reputations from two camps of people: people who have never worked on them to begin with, and people who have improperly tried to make a repair, like using Helicoils to replace head bolt threads. Sure, it'd be nice if the head bolt threads had no issues, but sometimes they do, and there's a right way and a wrong way to tackle the issue.
And a quick check of Time-sert's website shows that they make head bolt thread repair kits for a plethora of vehicles, Cadillac Northstars simply being one of them. BMWs, Ford Modulars, GM's High Feature 3.0/3.6L V-6 engines, GM's Atlas inline sixes and GEN-III V-8s, various Honda I-4 and V-6 engines, various Landie and Toyota engines, and even some Harley Davidson engines. Notice also that there are a number of Time-sert "Big-sert" kits, to be used after the failure of a Helicoil. People repair these things the wrong way all the time, and though it furthers the negative perception on these engines, it SHOULD reflect more on the improper repair than on the engine itself.