Here is my car situation: B58 engine that regularly does 2-mile trips each day, so engine often does not get up to operating temps. Northern michigan is 95 F in the summer and -10F in the winter. I will be running a tested and relatively trusted OTS (off the shelf) tune, increasing my horsepower from 320hp @ stock to 450hp @ Bootmod3 Stage 2+ (requiring upgraded catalytic converter and high pressure fuel pump). This tune will probably need 2 gallons of E85 and 12 gallons of 93 octane fuel (20% E85).
I will be taking regular logs of my engine to confirm health (no knocks, relatively small timing corrections, etc).
In essence, the car is daily driven, often for 2-4 miles per day, though sometimes for 100 miles per day, in the summer heat and winter freeze, and at a higher 450hp vis-a-vis stock 320hp, but using a tested and relatively trustworthy OTS tune.