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Years ago when I was a kid, someone sold my dad some really hot (fast) pistol powder when he asked for powder for reloading shotgun shells. We used (well tried to use) those reloads to shoot some skeet to improve our duck hunting skills. I had never heard a shotgun sound so much like a high power rifle.
Wrong type of powder, wrong amount of powder, for wrong application; like using gear lube in an engine or using too much ZDDP in a formulation.
If you examine page 13 of the Hodgdon Reloading manual:
http://www.imrpowder.com/PDF/Hodgdon Basic Manual.pdf
you will see 296 is about 50th fastest (out of 117) in the chart of powder burning rates.
Slower burning powders are used for large rifle calibers and magnum rifle loads, not pistol loads.
The .45 Colt IS a pistol round.
To improve performance in rifles chambered for Pistol cartridges, you want to hot rod the round for better accuracy and range, within the constraints of the rifle's modern steels and components.
I know about Internal and External Ballistics as I was one of those who wrote many of the early ballistics programs on the first personal computer, the ZX-81.
