I've now got 400 miles on my Detroit 4-53T swap into a 2009 Ford F350 and so far it's been great. I'm now learning how to program the 5R110 to shift cleaner on full throttle shifts as well as locking the torque convertor in 3rd. All in all very happy with the power delivery and overall function. Here's a quick tube video going through the gears in town.:
https://www.youtube.com/watch?v=1cOgPjSE8sc&t=8s
https://www.youtube.com/watch?v=1cOgPjSE8sc&t=8s