Depends.
Wife and kids won't eat the ends, but I finally got them trained to stop throwing them out--I paid for a whole loaf of bread, ends included. I often will microwave an egg and put it onto a slice of toast; an end works well enough there. Otherwise I'll make PB&J with it. But I rarely will eat two ends at once in a sandwich.
Now for homemade bread, usually the end is the first thing to get eaten! Slice that off, dab some butter on it... usually there is a contest as to who will get it. After some experimentation we found that just slice as needed, and leaving the loaf upside down on the cut end, yields the longest life--just leave it on the cutting board, on the counter. Don't know why but it works. Might not last as long as stuff in a bag, but way yummier. [Only problem is, getting slices small enough to make a sandwich with--which is why we haven't made any in a while.]