My Tundra rides ok but it has 70 series rubber to soak up the smaller bumps--and bigger ones still jostle me around. NVH is otherwise good. Larger vehicles tend to have better isolation, and if you are doing only highway driving the mpg penalty these days isn't as bad. [Except on a Tundra--it's thirsty no matter what.]
I do over 30k/year also and have two vehicles as a result. The gas savings from not driving my truck more than 5k/year pays for my car. Not saying that floating two vehicle payments is cheaper, no idea what taxes are like in your area, but if you only need a truck occasionally, perhaps two vehicles might be better than one.
I wonder if a Pentastar 1500 would be the best balance between mpg, price, comfort, if you could find one used for a decent price (I haven't looked in a while).