Do not tow in overdrive. I'm sure it will drive fine and there will be no discernible difference that you can tell. BUT, and there are many discussions on this, the "driven gear" in these ratios develop more heat with less ability to shed it, affecting the fluid in the mesh and potentially impacting those gears and components. While that's vague, and folks can argue it and provide equally vague information, my statement comes from an instrumented study I read years ago where they did thermal analysis on the transmission.
YMMV, but I won't tow in OD.
My 2018 F150 won't let me do so, either, and actually torque-limits the top 2 gears to approximately 1/3 of the throttle.