Our 2005 Chevy Silverado 2500HD 6.0 with the 4L80E .
I've done a flush at 100k miles and a pan drop drain and fill / filter change at 129K miles both with Dexron VI , vehicle currently has 145,409 miles on it.
I've towed a U-haul carhauler with a 1992 Ford F150 Reg cab truck on it 350 miles and taken a couple of trips to Atlanta, GA with it.
I've have had no issues with the trans.