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Epigenetics - Genes and the Environment - Celiac #4661241
02/09/18 06:09 PM
02/09/18 06:09 PM
Joined: Dec 2002
Posts: 41,513
'Stralia
Shannow Offline OP
Shannow  Offline OP
Joined: Dec 2002
Posts: 41,513
'Stralia
You are born with the genes that you are born with...epigenetics says that genes that are there CAN lie dormant, until something triggers them to express, then once switched on, you are at their mercy. (And they can be carried on to future geneations as holocaust survivor studies are showing)

Late last year my daughter, always robustly healthy started having serious stomach pains and cramping...she had noticed that she was getting bloated after eating for a couple months before that.

Given that apples don't fall far from their trees, she started using doctor google, and on her own volition decided to ditch gluten....felt much better, trailled herself with/without (pizza and garlic bread being the weak links)...she lost two pants sizes in a month (15 Y.O., now back to shopping in the childrens section)

We had the Christmas Cruise, and her US trip, so scheduled the proper testing to be after that (last week). Her own testing was pretty conclusive regarding sensitivity, so she (and her host family) managed very well over the period.

Test results came back yesterday.

One dominant and one recessive gene for Celiac, and the antibodies to show that she's reacting to it.

We've got a pretty good GP, who keeps up with everything, and he was explaining to her that it's her genes, they were sitting there, and she made it 14+ years before they activiated due to some response of her system to something in her environment. Could have made her whole life symptom free, but now they are switched on, it's lifestyle changes.

Looks like it came from wife's side of the tree.

Son is out with my wife at the moment getting blood drawn for his testing. He's a bit peeved at the concept that he too may have the issue, and has stocked the fridge with cocktail franks to gorge on before he finds out he can't/shouldn't eat them.

Funny thing with him is that when the GP went to order the blood work, son was shown as "deceased", as he hadn't shown up at any medical establishment for 7+ years...broken arm, chicken pox, shingles, and the formerly mentione robust health that my children have displayed.

Re: Epigenetics - Genes and the Environment [Re: Shannow] #4661243
02/09/18 06:10 PM
02/09/18 06:10 PM
Joined: Dec 2002
Posts: 41,513
'Stralia
Shannow Offline OP
Shannow  Offline OP
Joined: Dec 2002
Posts: 41,513
'Stralia
This modern understanding of how this works is great...not so long ago, she would have had to eat a gluten rich diet, and spend a fortnight in extreme discomfort before having a bowel biopsy to show what she had.

Re: Epigenetics - Genes and the Environment [Re: Shannow] #4661257
02/09/18 06:29 PM
02/09/18 06:29 PM
Joined: Dec 2015
Posts: 345
Ohio
Dorian Offline
Dorian  Offline
Joined: Dec 2015
Posts: 345
Ohio
Good luck to your daughter. I know about the discomfort and feel bad for her. Modern medicine is great though. Just imagine what it will be like in a few decades.


15 Camry Hybrid SE 48K 0W20 Kendall bulk
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Re: Epigenetics - Genes and the Environment [Re: Shannow] #4661479
02/09/18 11:00 PM
02/09/18 11:00 PM
Joined: Dec 2002
Posts: 42,288
New Jersey
JHZR2 Offline
JHZR2  Offline
Joined: Dec 2002
Posts: 42,288
New Jersey
I work with a guy who started to lose weight rapidly. Turns out he "developed" celiac in his 40s. Ditching gluten allowed him to regain weight. Interesting how and when these things present themselves,.

Re: Epigenetics - Genes and the Environment [Re: Shannow] #4661499
02/09/18 11:29 PM
02/09/18 11:29 PM
Joined: Jan 2018
Posts: 538
San Antonio, TX
das_peikko Offline
das_peikko  Offline
Joined: Jan 2018
Posts: 538
San Antonio, TX
I see some food products labelled "Gluten Free." I've always wondered what that meant.

Re: Epigenetics - Genes and the Environment [Re: Shannow] #4661505
02/09/18 11:42 PM
02/09/18 11:42 PM
Joined: Jul 2003
Posts: 4,891
New Zealand
Silk Offline
Silk  Offline
Joined: Jul 2003
Posts: 4,891
New Zealand
Parkinson's is the same, there is no known cause...but there are known triggers.


1987 BMW R65 - Aegis SAE30
2005 Nissan Expert - Gulf Western 10W-40
1996 Volvo T5 - Penrite HPR15 - 15W-60. Ryco syntec filter.
Re: Epigenetics - Genes and the Environment - Celiac [Re: Shannow] #4662735
02/11/18 10:07 AM
02/11/18 10:07 AM
Joined: Aug 2011
Posts: 3,385
Chicago,IL,USA
pandus13 Offline
pandus13  Offline
Joined: Aug 2011
Posts: 3,385
Chicago,IL,USA
kid #1 activated Celiac around 3 years old.
stomach bug pre-school epidemy and some hard headed doctors could not figure out her nightly vomit session and weight loss.
look at us like we had 3 heads..........

changed town and doctor, and she sent her to additional blood work 5 minutes into the visit

she's taller and heavier now, and I think she does no really react to slight cross-contamination.

Kid#2 did not got celiac positive at 3 years old.

Me and wife did not test positive

I suspect some stomach/GI issues on both our families may be from some granparents side....

It is not the end of the world these days,and especially since you cook kind of asian in your family, she will e OK.
Since you like spicy,get to exchange recipes with the TX guys for a tex-mex feeling.

One trait of some celiacs is being really sensitive (brain/feelings). Watch or that.


16 Golf SportWagen
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Re: Epigenetics - Genes and the Environment [Re: das_peikko] #4662741
02/11/18 10:11 AM
02/11/18 10:11 AM
Joined: Aug 2011
Posts: 3,385
Chicago,IL,USA
pandus13 Offline
pandus13  Offline
Joined: Aug 2011
Posts: 3,385
Chicago,IL,USA
Originally Posted By: das_peikko
I see some food products labelled "Gluten Free." I've always wondered what that meant.

a lot of time... Money. It is a fashion du jour to loose weight with it.
some Celiacs react to really really tiny amounts of cross-contamination.

Gluten-free is a question of how much non-contaminated and controlling all ingredients in a recipe.....


16 Golf SportWagen
13 Mazda5
08 Yaris
04 Elantra
95 accent
95 mystique
97 concorde
Re: Epigenetics - Genes and the Environment [Re: pandus13] #4662754
02/11/18 10:28 AM
02/11/18 10:28 AM
Joined: Dec 2002
Posts: 42,288
New Jersey
JHZR2 Offline
JHZR2  Offline
Joined: Dec 2002
Posts: 42,288
New Jersey
Originally Posted By: pandus13
Originally Posted By: das_peikko
I see some food products labelled "Gluten Free." I've always wondered what that meant.

a lot of time... Money. It is a fashion du jour to loose weight with it.
some Celiacs react to really really tiny amounts of cross-contamination.

Gluten-free is a question of how much non-contaminated and controlling all ingredients in a recipe.....


It does cost... But Ill say that when the person I mentioned above came down with it, the wife and I tried gluten free for a few weeks.

I had long heard, if youre encountering issues, first thing is "no wheat, no meat, and no dairy". We werent encountering anything, we did it literally for fun.

May be the placebo effect, but just going GF for a little while made us feel better, and we certainly dont exhibit celiac.

Laziness/being generally agreeable to wheat/etc. pushed us back into having gluten in moderation... But we will often buy GF pasta (we only eat pasta maybe twice or three times a month), and Ill also note that I feel less sluggish after a GF big pasta meal.

But we rarely eat bread/sandwiches/pasta, so while its still possible to eat a ton of guten, like most things for most everyone, moderation is key.

Re: Epigenetics - Genes and the Environment [Re: Shannow] #4662763
02/11/18 10:33 AM
02/11/18 10:33 AM
Joined: Mar 2017
Posts: 6,465
...
PimTac Offline
PimTac  Offline
Joined: Mar 2017
Posts: 6,465
...
Interesting subject. Thanks Shannow.

Testing like this might have helped me who went the first 55 years with no worries then suddenly diagnosed with type 2 diabetes. I had no inkling that I would be prone to it. No real family history either.


Cannot see signatures any longer so it doesn’t matter.
Re: Epigenetics - Genes and the Environment [Re: Shannow] #4682923
03/03/18 05:22 AM
03/03/18 05:22 AM
Joined: Dec 2002
Posts: 41,513
'Stralia
Shannow Offline OP
Shannow  Offline OP
Joined: Dec 2002
Posts: 41,513
'Stralia
Son got his results back Thursday.

Has the genes, not the antibodies. 95% of Coeliacs have the genotype...obviously not everyone with the genotype has triggered the immune flare up.

Gluten Free household it appears to be ('cept for me)...daughter will have a reaction to something so innocuous as wife making son a lunch wrap (wet with tomato), then cutting her lunch on the same board.

Naturally, wife is trying to make the transition expensively pain free...after school snacks jump from $2-3 to $7-10, because that's what he always has...Gluten free sausage rolls are like something (don't know what) wrapped in cardboard...but they are familiar in shape and accesibility.

We were alone (he and I) last night, so I made some Polenta with parmesan and thyme, cooled it, cut it, and grilled it with the Jerked Chicken...he loved it.

We need to work out gluten free stuff that people want to eat, not gluten free substitutes for three times the price and half the satisfaction.

Re: Epigenetics - Genes and the Environment [Re: Shannow] #4683395
03/03/18 05:11 PM
03/03/18 05:11 PM
Joined: Jul 2003
Posts: 4,891
New Zealand
Silk Offline
Silk  Offline
Joined: Jul 2003
Posts: 4,891
New Zealand
Yes, stay away from the whole gluten free band wagon, learn what their bodies need and how to achieve it. One of my daughters has a skin condition that goes away on a gluten free diet...but she doesn't stay gluten free...


1987 BMW R65 - Aegis SAE30
2005 Nissan Expert - Gulf Western 10W-40
1996 Volvo T5 - Penrite HPR15 - 15W-60. Ryco syntec filter.
Re: Epigenetics - Genes and the Environment [Re: pandus13] #4683437
03/03/18 05:47 PM
03/03/18 05:47 PM
Joined: Jun 2003
Posts: 10,534
Illinois
javacontour Offline
javacontour  Offline
Joined: Jun 2003
Posts: 10,534
Illinois
Yep, it's trendy for some and a necessity for others.

We had a neighbor who has Celiac disease, as did her late daughter.

Some meals at our home were "fun." There was the two of them. Then one of my daughters was vegan, the other vegetarian, and oilBabe has a number of food allergies/sensitivities.

The neighbor has moved to Alaska, the vegan daughter has backed off to vegetarian, but is living on her own in Seattle, so that's not a problem. oilBabe has a new allergist and the meds she takes help her cope. The other daughter is full carnivore again, and now I'm the complicated party with pre-diabetes, maybe stage 2, so I'm controlling my carbs...

The "fun" never ends.

Originally Posted By: pandus13
Originally Posted By: das_peikko
I see some food products labelled "Gluten Free." I've always wondered what that meant.

a lot of time... Money. It is a fashion du jour to loose weight with it.
some Celiacs react to really really tiny amounts of cross-contamination.

Gluten-free is a question of how much non-contaminated and controlling all ingredients in a recipe.....


network down, IP packets delivered via UPS -BOFH
Re: Epigenetics - Genes and the Environment [Re: Shannow] #4684938
03/05/18 08:54 AM
03/05/18 08:54 AM
Joined: Aug 2011
Posts: 3,385
Chicago,IL,USA
pandus13 Offline
pandus13  Offline
Joined: Aug 2011
Posts: 3,385
Chicago,IL,USA
Originally Posted By: Shannow
Son got his results back Thursday.

Has the genes, not the antibodies. 95% of Coeliacs have the genotype...obviously not everyone with the genotype has triggered the immune flare up.

Gluten Free household it appears to be ('cept for me)...daughter will have a reaction to something so innocuous as wife making son a lunch wrap (wet with tomato), then cutting her lunch on the same board.

Naturally, wife is trying to make the transition expensively pain free...after school snacks jump from $2-3 to $7-10, because that's what he always has...Gluten free sausage rolls are like something (don't know what) wrapped in cardboard...but they are familiar in shape and accesibility.

We were alone (he and I) last night, so I made some Polenta with parmesan and thyme, cooled it, cut it, and grilled it with the Jerked Chicken...he loved it.

We need to work out gluten free stuff that people want to eat, not gluten free substitutes for three times the price and half the satisfaction.

Cutting board use in common .... Yup the dreaded cross-contamination.

Since you just moved into the new place, You can make a "Gluten-free corner". The idea is buy your daughter new stuff (cutting board, set of cooking utensils, couple pots/fry pans ), and make sure only her use it. Wash separately and dry separately.
Then allocate (after a triple session of cleaning) a shelf in the fridge for her use only, and that's it.
You need to get a gage on what's the minimum she react to and keep it that way.
You (the rest of the family) can still eat non-gluten-free.
Also some costs for the special flours could be go down if you invest in an electric mill (rice, almond, beans, peas .... flours).
Since she was recently in US, she could try the Mexican style of eating. Avoid torta, farina, pan, salsa ingles, Knorr/Magi in recipes.
Also, I remember you cook with a indian/Asian flare: this is usually gluten-free.

It is not the end of the world...
The idea is to cook as much from scratch to control the ingredients. (I know you cook at home a lot, so should not be that much of an adjustment).

The commercial stuff, while they may fill a need on the go, they usually empty your wallet.

I had two "gluten-free on the road" threads: a lot of suggestions where made, plus we find out some gluten-free BITOG members....

Last edited by pandus13; 03/05/18 09:03 AM. Reason: ADHD cannot type

16 Golf SportWagen
13 Mazda5
08 Yaris
04 Elantra
95 accent
95 mystique
97 concorde
Re: Epigenetics - Genes and the Environment [Re: Shannow] #4685248
03/05/18 01:59 PM
03/05/18 01:59 PM
Joined: Dec 2002
Posts: 41,513
'Stralia
Shannow Offline OP
Shannow  Offline OP
Joined: Dec 2002
Posts: 41,513
'Stralia
Given that she's active, the son has the genes, just not the immune flare ups, and it came to them via my wife, I think it's gluten corner for me...we had the gluten free corner, but it's easier the other way.

Separate boards, separate butter, separate condiments...

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