Snow, unless you are getting the e85 for SIGNIFICANTLY cheaper than 87 octane, it will be a lose-lose situation. E85 has about 30% less energy than gasoline, so your mileage will go down accordingly. You don't appear to have a turbo or supercharger, so the cooling effect of the vaporization temp of e85 will be wasted as well, and if your engine is otherwise stock, the roughly 105 octane will hinder combustion as well.
If you're insistent on doing it, yes, you will likely need significant fuel system upgrades to deal with the corrosive nature of ethanol, and you will need injectors that are roughly 50% larger. This isn't including getting your ECM tuned to deal with the additional fueling requirements, and unless your truck had been flex fuel from the factory, fuel composition sensors will probably be waaay more expensive and involved than would ever be worth it. IMHO gasoline has been the primary mover of cars and light trucks for over 100 years for a good reason- it's energy-dense, readily available, and pretty cheap. That's still not going to change anytime soon.
