Well, since I own a high mileage car (180k), I know what automobiles are capable of. Granted, I purchased this one new. If I knew a vehicle's previous owner and history, it would not bother me as long as it is priced accordingly. Risk/benefit, higher miles equal higher risk, benefit of lower price for taking the risk.
1991 Chevrolet K1500 (4.3, 4x4, 86k miles)
2016 Dodge Grand Caravan
(3.6 V6) 46500 miles