I have an '01 5.4L Ford SuperCrew 4x4 that I purchased used in March of '02 with 10K miles on it. Since then I have logged 49897 miles consuming 3304 gallons of gas, 15.1mpg average. I have checked every tankful for mileage, the highest being 18.2 (58mph on level HWY) and the lowest 11.8 (towing a 3500# boat). I recorded a 1.2mpg drop in fuel economy average when MTBE was replaced with Ethanol. On my last tankful I started using Acetone at a mixture ratio of .25oz per gallon and my first report is: 366.4mi / 22.6gal = 16.2mpg.
This is only one tankful so I can't consider it a success. My first impression is good, thinking that I may have regained what I lost when Ethanol became our oxegenate here in CA. Like I said, I record every tank of fuel and this is the first of many. I will probably run 8-10 tanks then stop the Acetone blend and see if my mileage decreases.
My daily commute is a 12-mile round trip with some HWY speeds approaching 70mph and some two lane roads that rarely get faster than 25mph.
BTW- Over the past three years I have used Chevron, Shell, ARCO, Mobil and Union 76 gasolines with no recordable difference between them. Lately I've used Mobil and Shell 87 grade gas.