I'm on my 3rd set of Michelin Defender LTX M/S-2 (well, only the most recent set has had the "Defender" moniker) on my 2007 Tacoma that now has a total of almost 226K. I'm on my 4th set of tires, total, on the truck.
I get about 70K out of the LTX M/S-2, running slightly lower pressures than what's called for on my door jamb (I went up from the stock 265/70-16 to a 265/75-16). I was running 26F/29R, down from 29/32 stock pressures. This set, I decided to up the pressures to 35/35 in an attempt to coax some more life out of the tires. Because, in my opinion, I should be able to get more than the 70K they're warranted for in such a light truck. I've heard of guys with half-ton pickups getting more mileage on them than what I got.
I've been very happy with them overall, obviously. Yeah, they're expensive at over $800. But traction is great, and I especially love the wet traction. Resistance to aquaplaning is some of the best of any tire I've driven on.