......Typically, a loss of control of a cargo airplane, or a steep descent, is more likely the result of shifted cargo, on board fire, or simple mechanical failure...
This immediately comes to mind
Sadly It seems to be usually heavy cargo shift on takeoff that gets these cargo planes. It doesnt take much and takeoff is the one time in the flight that the aircraft tends to nose up more than just slightly. I knew a guy one that got killed in a Lancair high performance homebuilt. They say he left An airshow and did a zoom climb and a big pile of brochures fumbled way back into the rear of the cockpit pinning it into a hammerhead stall that was unrecoverable. Nothing but a big stack of paper killed him. It doesn't take much with aircraft to kill you with a sudden change in center of gravity.