I've put 33K miles on my 2022 so far. Mine is a crew cab, short bed 4x4 S-model.
Like said above, time will tell how well the VQ38DD and jatco copy of the MB 9G tronic do. I enjoy the power train. Good power, performance and economy. It does vibrate at idle a bit and the ride is stiff and jarring with just the driver in the truck. Super smooth with some weight in it. Most of your maintenance is easy to DIY. The transmission requires a specific plastic tool kit for draining, filling and level check and a fluid pump for filling. Doesn't look too bad though.
The hydraulic r/p steering is stiffer than you'll be accustomed to, but you get used to it.
Braking and handling are excellent.
I find the base halogen reflector headlamps to be excellent. So much better than other trucks I've owned.
Zero squeaks or rattles inside or out. Some of the body panel gaps are huge, but they're consistently huge if that makes sense.
If you choose the rare crew cab long wheel base/bed that can be had in the SV model, the turning radius is annoyingly huge for the size of truck. My FIL has a 2017 frontier configured this way. Short wheel base does not have this problem.
My only complaint with my S model is the only way to adjust the side view mirrors is by pressing against the glass with your digits like a caveman and there's no defrosters in them. Oddly, the mirrors are loaded with blind spot warning sensors and LEDs. First world problems..
I would recommend this truck and would buy another.