355 HP from a turbo 3.0L V6 nowadays is not much of an achievement considering there's plenty of N/A V6's pushing close to 300 HP. Not to say the 2021 TLX is not a fine car, just that getting 65 HP from turbo charging a modern V6 isn't really something to write home about.
Most of those V6's that are at or above 300hp are also at least a half liter bigger than this motor. When you look at one of the older 3.0 liter motors at 240hp you're talking about getting over 100+ more out of that displacement. And Honda LOVES to build a bunch of different versions of the same basic motor. Look how long the J Series has been in cars. Punch this new one out to 3.5L and tune it for low end and you have a great candidate for the bigger SUV's and Ridgeline.
As cautious and slow as Honda is to adopt 'new' things, this will probably be a very good motor. I'm a little more concerned about the 10 speed trans being able to put up with more than 350hp. It took them a few years to get the 5 speed right in my cars, so I'm on the fence about this one, although its been banging around in Accords and Odysseys for a while now.