Lots of discussion here there and everywhere. Well, almost everywhere.
Seen the tables that tell of how much to alter the torque setting if grease or anti-seize or oil etc. is placed upon the threads.
Forgot where I saw it but believe it wasn't a huge torque difference.
Some bellow to NEVER lube the lugs or the studs. Others have done it for years with no problem, apparently.
I did it now and then and more often back here in the land of salt on the road in winter.
Haven't done it to the Silverado yet since I see no evidence of any rust.
If i do will likely lightly coat the stud threads with that silver-colored anti-seize. As the biped above stated, the stuff seems to hang in there, not requiring reapplication every time a wheel is taken off and on.
Also, it doesn't subjectively appear to me that anti-seize adds as much "slipperiness" as oil or grease might. You gotta' have friction for a nut to stay where it's supposed to be.
While we're at it, remember to thank our friend friction because we'd be in deep doo doo if it wasn't there!!!!!!
An object in motion tends to stay in motion until acted upon by an outside force. Maybe chaos theory or quantum mechanics disagrees but supposing it's true.... without friction we would be living in a very fast-paced society in constant motion. Suggesting to others to slow down would be futile!!!!!!!
If you live where climatic and man-made conditions do not tend to promote rust, I doubt if you need to lube the lugs or studs. If rust is present or possible, may not do any harm to protect those threads. I would avoid anything that is too slippery, though. Just in case. Just to be safe. I guess.
If my advice leads to a wheel falling off and a major catastrophe occurring, don't bother suing. It ain't my shanty (I rent) and the Coot is basically broke.