A noisy wrist pin has been known to outlast the rest of the engine.
If the noise is locatable by the spark disable method then alternatly it could be a "loose" piston maybe caused by overheating.
A loose wristpin won't cause blowby or a loss of compression.
A loose piston likely will cause blowby or a loss of compression.
Usually a loose piston will improve on warmup and a wrist pin usually wont improve much if at all.
If each coil (assuming a distributorless system) feeds two cylinders you may have to ground the spark on the disabled cylinder to allow the associated coils other cylinder to fire.
If its a wrist pin...drive on something else will probably break first.
Good luck Sir.
Rickey.