RCT, I'm a believer in upper-cylinder lube but I confine it to (mostly) simpler, carbureted engines. Fuel injectors are finicky things and can clog ... sometimes a very expensive fix.
I used MMO in an '80s Ford Escort and I would routinely pick up about 3% better fuel economy. Also, the very slow oil consumption this car had would drop to absolutely zero as long as I had 2-3 ounces of MMO in each tank.
But because of the possibility of fouling injectors, I don't recommend this too much anymore. Might not be bad to try this in your Harley then keep strict records of your fuel economy and oil consumption. Possible protection of cylinder walls and/or valve seats will be harder to prove.
--- Bror Jace