Originally Posted By: SuzukiGoat
I believe the difference in viscocities force the thermostat to open at a slightly cooler temperature.
That's not how cooling system thermostats work though.
They work off the principle of something called a "wax motor", meaning a sealed capsule filled with wax that has a very specific melting point and that expands as it melts.
Basically, as it melts, it pushes the thermostat open- if it's fully melted, the thermostat is fully open, and if it's fully solidified, it's fully closed.
The point of all this is that it's engineered to automatically open/close enough to keep the temperature right in the band that the thermostat is rated for, at least assuming that the engine isn't generating too much heat to do that. As a matter of fact, they typically run about half open at operating temp, to give themselves some leeway if conditions change.
So if you're sailing down the highway on a hot day, it is likely that your thermostat isn't wide open since the air blowing through the radiator is cooling your coolant enough to start to solidify that wax pellet a little bit. It's also why your engine temp doesn't fluctuate like the thermostat's a totally open/totally shut valve that merely opens completely as the engine hits the ideal temp, and shuts completely as it cools down below that temp.
So the upshot of the whole thing is that it doesn't really matter whether you're using straight water or some mix of coolant/water- your thermostat will keep that coolant right where it's supposed to be automatically, due to that wax motor action.