I'm thinking 30,000 miles. I know the Tacoma V6 uses them and recommends 30k as a replacement interval. The car came with NGK OE Laser Iridium plugs that were changed to 1-step colder NGK plugs when I added more boost. It runs awesome on the V-Power plugs. I know I could use NGK's Iridium IX plugs and probably run them longer, but they cost over twice as much as the V-Power plugs and I'm not sure there is any benefit to them other than being able to leave them in for 100,000 miles. That just seems too long to me.