when I visit my wife at college in wyoming, on the way there is one ethanol free gas station, that I always get gas at, I seem to get 2+ mpg and a bit more power. I have about 8 different hand calculations on the mpg difference, and after getting the gas, its nothing but an uphill climb to laramie, wy from somewhere in nebraska, I highly doubt that going uphill will be advantageous mpg and power wise, as there is less air at higher altitudes(1.3 miles above sea level in laramie,wy).
But I personally believe I still don't have enough data points.