I found this interesting.
"It is the ester that can cause problems when you change from mineral to synthetic.
Ester base oil used alongside PAO base oil in lubricant formulation has excellent natural detergency. In other words, it will clean up varnish on component surfaces as a result of thermal and oxidative degradation of the lubricant. When you switch from a typical mineral-based engine oil to a typical synthetic-based oil, the varnish layer will be removed by the ester in the synthetic oil and become suspended. This suspended material can rapidly clog filters, block oil flow passageways and lead to component starvation. The same is true for gearboxes and other industrial machines.
So think twice about switching to synthetic oils in applications where the engine or other machine has been operating for some time with mineral oils. If you decide to make the switch, try to clean the system before making the change and then monitor it carefully once you start it up."
http://www.machinerylubrication.com/Read/28601/switch-to-synthetic
"It is the ester that can cause problems when you change from mineral to synthetic.
Ester base oil used alongside PAO base oil in lubricant formulation has excellent natural detergency. In other words, it will clean up varnish on component surfaces as a result of thermal and oxidative degradation of the lubricant. When you switch from a typical mineral-based engine oil to a typical synthetic-based oil, the varnish layer will be removed by the ester in the synthetic oil and become suspended. This suspended material can rapidly clog filters, block oil flow passageways and lead to component starvation. The same is true for gearboxes and other industrial machines.
So think twice about switching to synthetic oils in applications where the engine or other machine has been operating for some time with mineral oils. If you decide to make the switch, try to clean the system before making the change and then monitor it carefully once you start it up."
http://www.machinerylubrication.com/Read/28601/switch-to-synthetic