Although my DC-10 (-40) crew member experience is really limited, I thought it was a very complex, but problematic airplane. Certainly a Cadillac design over the early Boeing jets and maybe that was part of the problem.
Coming from the 727, it was a Second Officers dream (nightmare)...it had full electronic pressurization; you could transfer fuel between fuel tanks; it was quiet; it had a Delco INS for nav; it flew international routes, etc.
In my limited experience, it also was problem plagued- in the roughly 150 hours that I plumbed on it, I had landing gear problems (center gear), a center duct overheat/fire, boost pump cb's constantly popping, etc. You had to be really careful with thrust lever movements at altitude as I recall. I was amazed at the mechanical issues that I saw in such a short stint on the jet. In fairness, I had friends that flew it for years and loved it! Me, not so much. I was glad to go on to an F/O job on the 727.
I never saw the frequency of mechanical issues that I saw on this airframe in thousands of hours of flying on B 727's, 757's, 747-400's or Airbus 320 and 330 jets. Just my limited experience on the "Death Cruiser 10" from the mid-1980's...YMMV