Our home is zoned, so different areas are kept at different temperatures.
During the winter months the main living area is set to 68 during the day, and 60 at night (although it never drops more than a couple degrees overnight). That effectively shuts off the heat at night.
Our master bedroom/bath wing of the home is set to 65 during the day and 60 at night; we like it cool when we sleep. Even on the coldest nights it only drops 2-3 degrees overnight; this effectively shuts off the heat at night.
The wing of our home that has our spare bedrooms and my office is set for 68 during the day and 60 at night. Same as the other zones, this effectively shuts the heat off at night since the temperature doesn't drop more than 2-3 degrees. If we have guests they are allowed to change the temperature if they prefer it warmer or cooler.
The lower level zone with a family room, wine cellar, wifes office, utility room and bathroom is set to 62. The lower level has a wall of windows facing southwest, so during the day we capture the solar heat in the stone work, so the lower level is usually around 67 or 68 degrees. At night curtains are closed over the window wall to help keep the heat in, and the stonework gives up its warmth to the room. The lower level will usually drop back to 62 at night, so the heating system runs some to keep that at temperature. The lower level is built into the hillside, so half is underground and half is exposed. The half that is underground has the wine cellar and my wife's office in it, so it's quite easy to maintain proper temperatures in those rooms with a little adjustment of the dampers.
During the summer the cooling is set at 74 for most of the house. Our master bedroom suite is allowed to cool off to 68 at night, and if we have guests the guest bedrooms are allowed to cool off to a temperature of their choosing. The wine cellar has its own cooling system to maintain temperature during the summer. The rest of the lower level is kept around 70 by circulating the cooler air from the underground portion of the level, and on hot sunny days keeping the curtain wall closed to stop solar gain. The lower level of the house requires very little air conditioning during the summer; we make sure it runs enough to maintain property humidity though.
Our electric bills are less than $100/month, and propane costs are normally less than $1000/year, which includes the shop heat, clothing dryer, kitchen stove and outdoor grill.
