I experience inline 6s in 60's Fords and Chevys, and V6s by Chrysler, GMC, Buick and Ford. I'll take a V6, though I've not had a BMW inline. I'm sure I6s got better with fuel injection as far as economy, my 60's Chevy IIs usually got 18 MPG. My 2000 Concorde 2.7 V6 has gotten as high as 34 MPG on the highway.
I thought I6s were buzzy and had little low end torque, particularly the 170 Ford. I didn't like them and always liked V6s better.
Strange how much talk about how V6s were only developed to solve packaging problems when the GMC 305 and the Buick 231 were developed for RWD platforms. I think the first Ford 60 degree was for a RWD platform also.
I like V6s better.