I have one car I always use Loctite on - my 1988 Fiero.
I had an incident about 5-6 years ago where I started hearing a clunk every time I applied the brakes. Getting out to investigate, I found one of the rear caliper bolts had gone missing and the second bolt was working its way loose from use. The caliper was rocking back and forth every time I applied the brakes! Fortunately I had my tools with me (including the necessary T55 socket) and tightened the remaining bolt down good and snug. I also used some tie-wire where the other one had been, just in case. Made it home fine.
In all fairness, however, it turned out someone (a P.O.? a mechanic? I don't know) had disassembled that caliper some years earlier and re-assembled it with the slider on backwards (the sliders bolt solidly to the knuckle and the caliper glides back and forth on them). One end of the slider is countersunk to receive the bolt and the other is not, so with it mounted backwards the bolt was against the non-countersunk end and as a result only a couple threads were actually threaded into the knuckle. How long it had been that was was anyone's guess.