Vette owner - the blowout happened when a piece of metal (which must have been kicked up by a vehicle in front of me...but I never saw it) in the road cut a 3" gash in the tread. I was traveling at approximately 60 MPH on the highway. I felt and heard the BOOM of the tire failing and instant loss of all air (hence my use of the word catastrophic to describe it). The steering wheel and car started shaking and pulling to the right instantly from the flapping remains of the deflated carcase. By the time I stopped on the shoulder, the tire was destroyed, shreds of sidewall on the rim connected to what was left of the tread....what would you consider severe?
The trailer was actually destabilizing in its influence on the car, since it put more weight on the rear, altering the car's CG and reducing its directional control...and this blowout was on the right front.
The point is: worst case; heavily loaded, destabilized, instant blowout, is controllable if you don't make sudden, panic inputs.
To the OP - skip the run-flats. Take care of your tires. The Ford Explorers were all under-inflated, overloaded and every driver who rolled one, rolled it becasue they panicked... I've been driving for 34+ years...and I have only had one real blowout...if you take care of your tires, it's really unlikely.
If you don't panic, and simply drive the car, it's not that big of a deal when one happens.