As an ex Mercury marine engine tester, I can say, without any doubt, 100 to 1 will increase engine wear in highly loaded engines. I know, that lightly loaded 2 strokes, simply loafing along do just fine on 100 to 1. But, you must remember that even the manufacturers increase the ratio on variable systems. Outboards, for example, run 100 to 1 at idle and low power settings. And, that's perfectly fine. As there is plenty of oil remaining on the parts under those conditions (low airflow and load)
There are those who will make all sorts of unsubstantiated claims, possibly backed up with singular real world examples, and anecdotal results (I won't ever dismiss those results, drag racers are a great example of what people can do without scientific data). And, there are those of us who have been involved in actual, real world, scientific, 2 stroke oil testing. So, I am qualified to claim what I claim...
Disclaimer: I'm not the worlds leading expert on 2 stroke oils, just someone with experience in the field. Some time ago, I worked as a tech, under some incredibly intelligent and experienced individuals. Our goal was not to determine what oil was best. Rather, we were interested in gaining a competitive advantage, with production based engines. Testing was based on oil ratio and power output. Wear rates were a key aspect of the testing, as these engines needed to go a full season without overhaul.